International Review of Ophthalmology ›› 2014, Vol. 38 ›› Issue (3): 164-169.doi: 10.3760/ cma. j. issn.1673-5803.2014.03.005

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Molecular mechanism of bone marrow\|derived cells in  the development of ocular neovascularization

 GAO  Fan, WANG  Yu-Sheng, HOU  Hui-Yuan   

  1. Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Forth Military Medical University, Xi’an Shaanxi 710032, China
  • Received:2013-12-05 Online:2014-06-22 Published:2014-06-23
  • Contact: HOU Hui-yuan, Email: hhywyyx@163.com

Abstract: Ocular neovascularization is a significant contributor to visual impairment in many eye diseases. Bone marrow\|derived cells (BMCs) play important roles in the development of ocular neovascularization, in which BMCs are believed to undergo the steps of mobilization, migration, adhesion and differentiation. This process is delicately regulated and affected by multiple factors, including aging, smoking, and so on. Now it has become a research hotspot to investigate the molecular mechanism of BMCs involved ocular neovascularization, which is imperative for further studies on pathogenesis of ocular neovascularization and treatment strategies using BMCs as targets. (Int Rev Ophthalmol, 2014, 38: 164-169)